Medical Therapy for Crohn’s Disease: Top-Down or Step-Up?
نویسندگان
چکیده
منابع مشابه
Medical therapy for Crohn's disease: top-down or step-up?
The emergency of effective biological therapy in the treatment of Crohn's disease (CD) has led to a clinical debate about 'step-up versus top-down strategy'. Step-up refers to the classic therapeutic approach, namely progressive intensification of treatment as disease severity increases. Top-down refers to the early introduction, in all CD patients, of intensive therapies, including biological ...
متن کاملTop-down or step-up treatment in Crohn's disease?
In recent years, a change in the treatment goals for patients with Crohn's disease (CD) has come under intense discussion. Whereas 10 years ago treatment was initiated mainly in reaction to acute flares of the disease aimed to improve clinical symptoms, the focus now has changed to the prevention of damage to the intestinal wall. The prevention of structural damage by achievement of 'mucosal he...
متن کاملGuest editorial: SELECT A SUITABLE TREATMENT STRATEGY FOR CROHN’S DISEASE: STEP-UP OR TOP-DOWN
Crohn’s Disease (CD) is a chronic immune-mediated disorder with progressive and destructive course. Current guidelines on the treatment strategy still recommend a step-up approach with sequential prescription of corticosteroids and immunosuppressives. However, mounting evidences manifested that top-down therapy with early administration of anti-TNF or combination of immunosuppressives can achie...
متن کاملSelect a suitable treatment strategy for Crohn's disease: step-up or top-down
Crohn's Disease (CD) is a chronic immune-mediated disorder with progressive and destructive course. Current guidelines on the treatment strategy still recommend a step-up approach with sequential prescription of corticosteroids and immunosuppressives. However, mounting evidences manifested that top-down therapy with early administration of anti-TNF or combination of immunosuppressives can achie...
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This retrospective-medical-record review was conducted to evaluate effect of infliximab therapy, particularly with a top-down strategy, on the nutritional parameters of children with Crohns disease (CD). 42 patients who were diagnosed with Crohns disease at the Pediatric Gastroenterology center of a tertiary care teaching hospital and achieved remission at two months and one year after beginnin...
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ژورنال
عنوان ژورنال: Digestive Diseases
سال: 2007
ISSN: 0257-2753,1421-9875
DOI: 10.1159/000103897